Job no: 514653 Work type: Fixed term - Full-time Campus: Adelaide Categories: Faculty of Health & Medical Sciences, Level A (Level A) $78,544 to $105,611 or (Level B) $111,031 to $131,335 per annum plus an employer contribution of 17% superannuation applies.Fixed term, full time position available for 24 months.The 3 D Chromatin Organisation Lab (PI Dr Joanna Achinger-Kawecka) is seeking a postdoctoral researcher to work on the interphase of chromatin structure, epigenetics and transcriptomics.The applicant should have experience in epigenetics and/or chromatin field, a good publication record and be motivated to independently shape their own projects.The Lab's research focuses on understanding the role of 3 D chromatin alterations in driving cancer development, progression and treatment resistance.We use cutting-edge methods (multi-omics, single-cell, genome editing as well as various pre-clinical model systems) to study the interplay of the 3 D chromatin, epigenome and transcriptome in cancer.About the project: The successful candidate will use cutting-edge experimental and bioinformatics approaches to understand the dynamic and specific 3 D chromatin organization in cancer cells and its interaction with non-coding elements and transcription factors.The applicant will implement a number of new multi-omics approaches, including different chromosome conformation capture-based methods (Hi-C, Capture Hi-C, Hi Ch IP, Pore-C) and the development of high-throughput single-cell and spatial 3 D genome, epigenome and transcriptome profiling technologies.The applicant will have on-site access to core equipment and facilities for epigenetics studies, such as high-performance computing, NGS sequencing, imaging, tissue culture, animal facility and flow cytometry.Your responsibilities: Implement and optimize cutting-edge genomics technologies (e.g.Hi-C, RNA-seq, CUT&RUN/Tag, ATAC-seq, WGBS, Nanopore) Analyse high-throughput next-generation sequencing (NGS) data Supervise student projects at Honours, MSc and Ph D level Write reports and research articles, as well as grant proposals, and regularly participate in domestic and international conferences and workshops to present your own work To be successful at the Level A position you will need: Ph D in relevant biological subject (molecular biology, biochemistry, genetics or related) or near completion Laboratory experience in a wide range of standard molecular and cell biology techniques, such as mammalian cell culture, nucleic acid isolation, and DNA / RNA / protein / chromatin extraction and analysis Ability to rapidly learn new techniques and to tackle experimental bottlenecks creatively Excellent problem-solving abilities and good understanding of basic statistics Excellent communication skills (oral and written) To be successful at the Level B position you will need: Ph D in relevant discipline (Biology, Genetics, Biomedicine, Bioinformatics, Computational Biology, ...) Expertise in molecular biology and genomics technologies, particularly in chromatin structure, transcriptomics or epigenetics and/or integrative analyses of experimental datasets (e.g.3 D Genome, RNA-seq, Ch IP-seq/CUT&RUN/Tag, DNA methylation, chromatin accessibility).Good publication record with evidence of independence Experience in mammalian cell culture Programming experience in at least one programming language (preferably R or Python) and experience with NGS data processing pipeline is highly desirable If you have the talent, we'll give you the opportunity.Together, let's make history.Click on the 'Apply Now' button to be taken through to the online application form.Please ensure you submit a cover letter, resume, and upload a document that includes your responses to all of the selection criteria for the position as contained in the position description or selection criteria document.The University reserves the right to close this advertisement before the closing date if a suitable candidate is identified.For further information For a confidential discussion regarding this position, contact: Dr Joanna Achinger-Kawecka Group Leader, SAi GENCI E: The University of Adelaide is an Equal Employment Opportunity employer committed to providing a working environment that embraces and values diversity and inclusion.Female applicants, people with a disability and/or and Aboriginal and Torres Strait Islander people who meet the requirements of this position are strongly encouraged to apply.If you have any support or access requirements, we encourage you to advise us at the time of application.Advertised: 19 Aug 2024 12:00 AM Applications close: 15 Oct 2024 11:55 PM #J-18808-Ljbffr