Organisation/Company: UNIVERSITY OF SYDNEYResearch Field: Medical sciencesResearcher Profile: First Stage Researcher (R1)Country: AustraliaApplication Deadline: 21 Nov 2024 - 00:00 (UTC)Type of Contract: OtherJob Status: Full-timeIs the job funded through the EU Research Framework Programme? Not funded by a EU programmeIs the Job related to staff position within a Research Infrastructure? NoOffer DescriptionFull time fixed term for 3 years at Charles Perkins CentreExciting opportunity for a Principal Investigator to contribute to research focused project within the Save Sight Institute located at Charles Perkins CentreBase Salary $181,166 - $199,585 + 17% superannuationAbout the opportunityWe are seeking an innovative and motivated RNA Engineer to join our research team at the Save Sight Institute, Camperdown Campus, University of Sydney. The successful candidate will spearhead the development of novel oligonucleotide-based therapies targeting metabolic and mitochondrial dysfunction in optic nerve diseases, such as glaucoma and inherited mitochondrial disorders. This position involves advancing candidate RNA therapeutic platforms and integrating them into the Optic Nerve Research Collaborative Australia (ORCA), a national initiative focused on breakthroughs in optic nerve disease research.The ideal candidate will have a proven track record of innovation in RNA technology and experience in translating novel platforms into preclinical or clinical programs. An interest in entrepreneurship and commercialization is highly desirable, as the role offers opportunities for involvement in biotech start-ups and spin-off ventures. Based at the Save Sight Institute, Camperdown Campus, within the Faculty of Medicine and Health at the University of Sydney, the candidate is expected to actively contribute to the broader medical research community at USyd, fostering collaboration and mentorship. This is a unique opportunity to work at the cutting edge of RNA therapeutics in ophthalmology, with a direct impact on the treatment of optic nerve diseases.Your key responsibilities will be to:take a lead role in establishing and leading an innovative research group that develops and translates therapeutic oligonucleotides for optic nerve and neurodegenerative diseasesexpand our expertise in computational design of ribonucleic acids (RNA) for enhancement (processing, nuclear export, translatability of RNA), inhibition (antisense, RNAi) or repair (spliceosome-mediated RNA trans-splicing, CRISPR/Cas-triggered RNA-guided genome editing) of gene expression towards diagnosis and treatment of human diseasescontribute to leading a section of a major research program developing new treatments for glaucoma and optic nerve diseasecontribute and coordinate to the research and administration activities of the disciplinedevelop research collaborations which will ultimately result in knowledge or technology transfer leading to commercialization, improved policy or practice and/or enhancements to industryassist with future grant applications and supervision of PhD studentsAbout youhave a PhD in an academic field relevant to the disciplinedemonstrate strong expertise and experience in undertaking oligonucleotide therapeutic developmenthave demonstrated expertise in the design and conduct of translational researchadvanced expertise in in-silico, lab-based and pre-clinical research with a proven focus on gene and RNA therapy design and translationexperience in and proven ability to supervise standard molecular biology techniquesdemonstrates a track record of impactful research and publications in their fielddemonstrates a track record in innovation, enterprise and development of therapeutic candidates through to pre-clinical phasedemonstrated ability to be an excellent mentor for junior scientists as evidenced by supervision, mentoring, and supportdemonstrates a strong track record of effectively working in multi-disciplinary teams, industry and professional institutions, health partners, and stakeholdersYour employment is conditional upon the completion of all role required pre-employment or background checks in terms satisfactory to the University. Similarly, your ongoing employment is conditional upon the satisfactory maintenance of all relevant clearances and background check requirements. If you do not meet these conditions, the University may take any necessary step, including the termination of your employment.Applications (including a cover letter, CV, and any additional supporting documentation) can be submitted via the Apply button at the top of the page.For a confidential discussion about the role, or if you require reasonable adjustment or any documents in alternate formats, please contact Deepna Chand, Recruitment Operations by email to Deepna.Chand@sydney.edu.au.Copyright The University of SydneyThe University reserves the right not to proceed with any appointment.
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